A China Eastern Airlines aircraft with 132 people on board crashed in mountains in south China on Monday while on a flight from the city of Kunming to Guangzhou, China's Civil Aviation Administration of China (CAAC) said.
The number of casualties and reason for the crash are not yet known.
Rescue crews have been deployed to the area.
Flight MU5735 left Kunming at 13:11 local time (05:11 GMT) and was scheduled to arrive Guangzhou at 15:05.